IteraMed and Kinney References

50. “Recent Intellectual Property Law Changes and their Impact on Drug Discovery” W. A. Kinney, Curr. Top. Med. Chem. 2010, 10, 1927-1928.

49. “Strategies for Strengthening Patent Protection of Pharmaceutical Inventions in Light of Federal Court Decisions” X. Pillai, W. A. Kinney, Curr. Top. Med. Chem. 2010, 10, 1929-1936.

48. “Urotensin-II Receptor Modulators as Potential Drugs” B. E. Maryanoff, W. A. Kinney, J. Med. Chem. 2010, 53, 2695-2708.

47. “Nonpeptide Urotensin-II Receptor Antagonists: A New Ligand Class Based on Piperazino-Phthalimide and Piperazino-Isoindolinone Subunits” E. C. Lawson, D. K. Luci, S. Ghosh, W. A. Kinney, C. H. Reynolds, J. Qi, C. E. Smith, Y. Wang, L. K. Minor, B. J. Haertlein, T. J. Parry, B. P. Damiano, B. E. Maryanoff, J. Med. Chem. 2009, 52, 7432–7445.

46. “Generation of Novel, Potent Urotensin-II Receptor Antagonists by Alkylation–Cyclization of Isoindolinone C3-Carbanions” D. K. Luci, E. C. Lawson, S. Ghosh, W. A. Kinney, C. E. Smith, J. Qi, Y. Wang, L. K. Minor, B. E. Maryanoff, Tetrahedron Lett. 2009, 50, 4958-4961.

45. “Thrombogenic Collagen-Mimetic Peptides: Self-Assembly of Triple Helix-Based Fibrils Driven by Hydrophobic Interactions” M. A. Cejas, W. A. Kinney, C. Chen, J. G. Vinter, H. R. Almond, Jr., K. M. Balss, C. A. Maryanoff, U. Schmidt, M. Breslav, A.Mahan, E. Lacy, C. Yang, B. E. Maryanoff, Proc. Natl. Acad. Sci. USA 2008, 105, 8525-8530.

44. “Efficient, Enantioselective Synthesis of a alpha,beta-disubstituted Carboxylic Acid by Ru-XylPhanePhos-Catalyzed Asymmetric Hydrogenation” G. A. Grasa, A. Zanotti-Gerosa, S. Ghosh, C. A. Teleha, W. A. Kinney, B. E. Maryanoff, Tetrahedron Lett. 2008, 49, 5328–5331.

43. “Synthesis of an alphaVbeta3 Integrin Antagonist Intermediate via Asymmetric Hydrogenation of an alpha,beta-Unsaturated Ester with BoPhoz-Iridium and Rhodium Catalysts” A. Zanotti-Gerosa, W. A. Kinney, G. A. Grasa, J. Medlock, A. Seger, S. Ghosh, C. A. Teleha, B. E. Maryanoff, Tetrahedron: Asymmetry 2008, 19, 938-944.

42. “Suzuki–Miyaura Approach to JNJ-26076713, an Orally Active Tetrahydroquinoline-Containing alphaVbeta3/alphaVbeta5 Integrin Antagonist. Enantioselective Synthesis and Stereochemical Studies” W. A. Kinney, C. A. Teleha, A. S. Thompson, M. Newport, R. Hansen, S. Ballentine, S. Ghosh, A. Mahan, G. Grasa, A. Zanotti-Gerosa, J. Dingenen, C. Schubert, Y. Zhou, G. C. Leo, D. F. McComsey, R. J. Santulli, B. E. Maryanoff , J. Org. Chem. 2008, 73, 2302-2310.

41. “Studies with an Orally Bioavailable alphaVbeta3/alphaVbeta5 Integrin Antagonist in Animal Models of Ocular Vasculopathy: Retinal Neovascularization in Mice and Retinal Vascular Permeability in Diabetic Rats” R. J. Santulli, W. A. Kinney, S. Ghosh, B. L. DeCorte, L. Liu, R. W. A. Tuman, Z. Zhou, N. Huebert, S. E. Bursell, A. C. Clermont, M. B. Grant, L. C. Shaw, S. A. Mousa, R. A. Galemmo, Jr., D. L. Johnson, B. E. Maryanoff, B. P. Damiano, J. Pharmacol. Exp. Ther. 2008, 324, 894-901.

40. “Phenylpiperidine-Benzoxazinones as Urotensin-II Receptor Antagonists: Synthesis, SAR, and In Vivo Assessment” D. K. Luci, S. Ghosh, C. E. Smith, J. Qi, Y. Wang, B. Haertlein, T. J. Parry, J. Li, H. R. Almond, Jr., L. K. Minor, B. P. Damiano, W. A. Kinney, B. E. Maryanoff, E. C. Lawson, Bioorg. Med. Chem. Lett. 2007, 6489–6492.

39. “Nanoparticles That Display Short Collagen-Related Peptides. Potent Stimulation of Human Platelet Aggregation by Triple Helical Motifs” M. A. Cejas, C. Chen, W. A. Kinney, B. E. Maryanoff, Bioconjugate Chem. 2007, 18, 1025-1027.

38. “Collagen-Related Peptides: Self-Assembly of Short, Single Strands into a Functional Biomaterial of Micrometer Scale” M. A. Cejas, W. A. Kinney, C. Chen, G. C. Leo, B. A. Tounge, J. G. Vinter, P. P. Joshi, and B. E. Maryanoff, J. Am. Chem. Soc. 2007, 129, 2202-2203.

37. “Selection of a 2-Azabicyclo[2.2.2]octane-based alpha4beta1 Iintegrin Antagonist as an Inhaled Anti-asthmatic Agent” E. C. Lawson, R. J. Santulli, A. B. Dyatkin, S. A. Ballentine, W. M. Abraham, S. Rudman, C. P. Page, L. de Garavilla, B. P. Damiano, W. A. Kinney, B. E. Maryanoff., Bioorg. Med. Chem. 2006, 14, 4208-4216.

36. “Convenient Preparation of Aryl-Substituted Nortropanes by Suzuki-Miyaura Methodology” S. Ghosh, W. A. Kinney, D. A. Gauthier, E. C. Lawson, T. Hudlicky, B. E. Maryanoff., Can. J. Chem. 2006, 84, 555-560.

35. “Synthesis and Biological Evaluation of 1,2,4-Triazolo[2,3-a]pyrrole Derivatives as Alpha-4 (alpha4) Integrin Antagonists” E. C. Lawson, W. A. Kinney, R. J. Santulli, C. M. Fisher, B. P. Damiano, B. E. Maryanoff, Lett. Drug Des. Disc., 2005, 2, 601-605.

34. “Aza-Bicyclic Amino Acid Carboxamides as alpha4beta1/alpha4beta7 Integrin Receptor Antagonists” A. B. Dyatkin, Y. Gong, T. A. Miskowski, E. S. Kimball, S. M. Prouty, M. C. Fisher, R. J. Santulli, C. R. Schneider, N. H. Wallace, P. J. Hornby, C. Diamond, W. A. Kinney, B. E. Maryanoff, B. P. Damiano, W. Hei, Bioorg. Med. Chem. 2005, 13, 6693-6702.

33. “1,2,3,4-Tetrahydroquinoline-Containing alphaVbeta3 Integrin Antagonists with Enhanced Oral Bioavailability” S. Ghosh, R. J. Santulli, W. A. Kinney, B. L DeCorte, L. Liu, J. M. Lewis, J. C. Proost, G. C. Leo, J. Masucci, W. E. Hageman, A. S. Thompson, I. Chen, R. Kawahama, R. W Tuman, R. A. Galemmo, Jr., D. L. Johnson, B. P. Damiano, B. E. Maryanoff, Bioorg. Med. Chem. Lett. 2004, 14, 5937-5941.

32. “Piperidine-Containing gamma-Aryl Propionic Acids as Potent Antagonists of alphaVbeta3/alphaVbeta5 Integrins” B. De Corte, W. A. Kinney, L. Liu, S. Ghosh, L. Brunner, W. J. Hoekstra, R. J. Santulli, R. W. Tuman, J. Baker, C. Burns, J. C. Proost, B. A. Tounge, B. P. Damiano, B. E. Maryanoff, D. L. Johnson, R. A Galemmo, Jr., Bioorg. Med. Chem. Lett. 2004, 14, 5227-5232.

31. “Aza-bicyclic Amino Acid Sulfonamides as alpha4beta1/alpha4beta7 Integrin Antagonists” A. B. Dyatkin, W. J. Hoekstra, W. A. Kinney, M. Kontoyianni, R. J. Santulli, E. S. Kimball, M. C. Fisher, S. M. Prouty, W. M. Abraham, P. Andrade-Gordon, D. J. Hlasta, W. He, P. J. Hornby, B. P. Damiano, B. E. Maryanoff, Bioorg. Med. Chem. Lett. 2004, 14, 591-596.

30. “Structure-Function Study of Quinazolinone-Based Vitronectin Receptor (αVβ3) Antagonists: Computer-Assisted Analysis of Ligand-Receptor Interactions” E. C. Lawson, W. A. Kinney, M. J. Costanzo, W. J. Hoekstra, J. A. Kauffman, D. K. Luci, R. Santulli, B. A. Tounge, S. C. Yabut, P. Andrade-Gordon and B. E. Maryanoff, Lett. Drug Design Discov. 2004, 1, 14-18.

29. “A Concise Synthesis of an Indenopyrrolidine-Based Dual alphaVbeta3/alphaVbeta5 Integrin Antagonist” D. K. Luci, R. J. Santulli, D. A. Gauthier, B. A. Tounge, S. Ghosh, J. C. Proost, W. A. Kinney, B. DeCorte, R. A. Galemmo, Jr., J. M. Lewis, W. E. Dorsch, M. W. Wagaman, B. P. Damiano, B. E. Maryanoff, Heterocycles 2004, 62, 543-557.

28. “Structure-Function Analysis of Urotensin II and Its Use in the Construction of a Ligand-Receptor Working Model” W. A. Kinney, H. R. Almond, Jr., J. Qi, C. E. Smith, R. J. Santulli, L. de Garavilla, P. Andrade-Gordon, D. S. Cho, A. M. Everson, M. A. Feinstein, P. A. Leung, B. E. Maryanoff, Angewandte Chemie, Int. Ed. 2002, 41, 2940-2944.

27. “The Heck Reaction with Unprotected Allylic Amidines and Guanidines” E. C. Lawson, W. A. Kinney, D. K. Luci, S. C. Yabut, D. Wisnoski, B. E. Maryanoff, Tetrahedron Lett. 2002, 43, 1951-1953.

26. “The Synthesis of Spermine Analogs of the Shark Aminosterol Squalamine” Y. Shu, S. R. Jones, W. A. Kinney, and B. S. Selinsky, Steroids 2002, 67, 291-304.

25. “A Spermine-Coupled Cholesterol Metabolite from the Shark with Potent Appetite Suppressant and Antidiabetic Properties” M. Zasloff, J. I. Williams, Q. Chen, M. Anderson, T. Maeder, K. Holroyd, S. Jones, W. A. Kinney, K. R. Cheshire, Int. J. Obesity 2001, 25, 689-697.

24. “A Short Formal Synthesis of Squalamine from a Microbial Metabolite” W. A. Kinney, X. Zhang, J. I. Williams, S. Johnston, R. S. Michalak, M. Deshpande, L. Dostal, J. P. N. Rosazza, Org. Lett. 2000, 2 (19), 2921-2922.

23. “Aminosterols from the Dogfish Shark Squalus acanthias” M. R. Rao, A. E. Shinnar, L. A. Noecker, T. L. Chao, B. Feibush, B. Snyder, I. Sharkansky, A. Sarkahian, X. Zhang, S. R. Jones, W. A. Kinney, M. Zasloff, J. Nat. Products 2000, 63 (5), 631-635.

22. “Synthesis of an Azido Spermidine Equivalent” A. L. Weis, T. Bakos, I. Alferiev, X. Zhang, B. Shao, W. A. Kinney, Tetrahedron Lett. 1999, 40, 4863-4864.

21. “Synthesis of Squalamine Utilizing a Readily Accessible Spermidine Equivalent” X. Zhang, M. N. Rao, S. R. Jones, B. Shao, P. Feibush, M. McGuigan, N. Tzodikov, B. Feibush, I. Sharkansky, B. Snyder, L. M. Mallis, A. Sarkahian, S. Wilder, J. E. Turse, W. A. Kinney, H. J. Kjaersgaard, R. S. Michalak, J. Org. Chem. 1998, 63, 8599-8603.

20. “Squalamine Inhibits Angiogenesis and Solid Tumor Growth in Vivo and Perturbs Embryonic Vasculature” A. K. Sills, Jr., J. I. Williams, B. M. Tyler, D. S. Epstein, E. P. Sipos, M. P. McLane, S. Pitchford, K. Cheshire, F. H. Gannon, W. A. Kinney, T. L. Chao, J. D. Davis, M. Donowitz, J. Laterra, M. Zasloff, H. Brem, Cancer Research 1998, 58, 2784-2792.

19. “Efficient Route to 7-alpha-(Benzoyloxy)-3-dioxolane Cholestan-24(R)-ol, a Key Intermediate in the Synthesis of Squalamine” S. R. Jones, B. S. Selinsky, M. N. Rao, X. Zhang, W. A. Kinney, F. S. Tham, J. Org. Chem. 1998, 63, 3786-3789.

18. “Pseudoceratidine: A Marine Natural Product with Antifouling Activity. Synthetic and Biological Studies,” J. A. Ponasik, S. Conova, D. Kinghorn, W. A. Kinney, D. Rittschof, B.Ganem, Tetrahedron 1998, 54, 6977-6986.

17. “Some Reaction Safety Aspects of Ruthenium-Catalyzed Allylic Oxidations of delta-5-Steroids in the Pilot Plant” M. Harre, R. Haufe, K. Nickisch, P. Weinig, H. Weinmann, W. A. Kinney, X. Zhang, Org. Proc. Res. Dev. 1998, 2, 100-104.

16. “Design and Synthesis of [2-(8,9-Dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethyl]-phosphonic Acid (EAA-090), a Potent N-Methyl-D-aspartate Antagonist, via the Use of 3-Cyclobutene-1,2-dione as an Achiral alpha-Amino Acid Bioisostere” W. A. Kinney, M. Abou-Gharbia, D. T. Garrison, J. Schmid, D. M. Kowal, D. R. Bramlett, T. L. Miller, R. P. Tasse, M. M. Zaleska, J. A. Moyer, J. Med. Chem. 1998, 41, 236-246.

15. “Practical Approaches to Remote Asymmetric Induction in Steroidal Side-Chains Utilizing Oxazaborolidine Reagents” M. N. Rao, M.A. McGuigan, X. Zhang, Z. Shaked, W. A. Kinney, M. Bulliard, B. Laboue, N. Lee, J. Org. Chem 1997, 62, 4541-4545.

14. “The Synthesis and Characterization of Analogs of the Antimicrobial Compound Squalamine: 6-beta-Hydroxy-3-aminosterols Synthesized from Hyodeoxycholic Acid” S. R. Jones, W. A. Kinney, X. Zhang, L. M. Jones, B. S. Selinsky, Steroids 1996, 61, 565-571.

13. “The 3-Cyclobutene-1,2-dione Group: Versatile Template for Bioisostere Construction” W. A. Kinney, Phosphorus, Sulfur, and Silicon 1996, 109-110, 305-308.

12. “Synthesis of Squalamine, an Anti-Infective Steroidal Polyamine” A. D. Pechulis, F. H. Bellevue III, C. L. Cioffi, S. G. Trapp, J. P. Fojtik, A. A. McKitty, W. A. Kinney, L. L. Frye, J. Org. Chem. 1995, 60, 5121-5126.

11. “Stereoselective Synthesis of Squalamine Dessulfate” R. M. Moriarty, L. A. Enache, W. A. Kinney, C. S. Allen, J. W. Canary, S. M. Tuladhar, L. Guo, Tetrahedron Lett. 1995, 36, 5139-5142.

10. “Synthesis of 3-Hydroxy-3-cyclobutene-1,2-dione Based Amino Acids” E. F. Campbell, A. K. Park, W. A. Kinney, R. W. Fengl, L. S. Liebeskind, J. Org. Chem. 1995, 60, 1470-1472.

9. “Synthesis of Alkyl Substituted Cyclobutenediones by Free Radical Chemistry. Carbon for Nitrogen Replacement in the alpha-Amino Acid Bioisostere – 1,2-Diamino-1-cyclobutene-3,4-dione” W. A. Kinney Tetrahedron Lett. 1993, 2715-2718.

8. “3-Hydroxy-3-cyclobutene-1,2-dione: Application of a Novel Carboxylic Acid Bioisostere to an In Vivo Active Non-tetrazole Angiotensin-II Antagonist” R. M. Soll, W. A. Kinney, J. Primeau, L. Garrick, R. J. McCaully, T. Colatsky, G. Oshiro, C. H. Park, D. Hartupee, V. White, J. McCallum, A. Russo, J. Dinish, A. Wojdan, Bioorg. Med. Chem. Lett. 1993, 3, 757-760.

7. “Bioisosteric Replacement of the alpha-Amino Carboxylic Acid Functionality of 2-Amino-5-phosphonopentanoic Acid (AP5) Yields Unique 3,4-Diamino-4-cyclobutene-1,2-dione Containing NMDA Antagonists” W. A. Kinney, N. E. Lee, D. T. Garrison, E. J. Podlesney Jr., R. R. Notvest, J. T. Simmonds, D. Bramlett, D. M. Kowal, R. P. Tasse, J. Med. Chem. 1992, 35, 4720.

6. “N-Phenyl-2-pyridinecarbothioamides as Gastric Mucosal Protectants” W. A. Kinney, N. E. Lee, R. M. Blank, C. A. Demerson, C. S. Sarnella, N. T. Scherer, G. N. Mir, L. E. Borella, J. F. DiJoseph, C. Wells, J. Med. Chem. 1990, 327.

5. “A General Approach to Annulated 4-Cyclooctenones by Aliphatic Claisen Rearrangement. Stereospecific Total Synthesis of Precapnelladiene” W. A. Kinney, M. J. Coghlan, L. A. Paquette, J. Am. Chem. Soc. 1985, 107, 7352.

4. “Claisen Rearrangement of 6-Alkenyl-2-methylenetetrahydropyrans. A New Approach to Annulated 4-Cyclooctenones and a Stereospecific Synthesis of Precapnelladiene” W. A. Kinney, M. J. Coghlan, L. A. Paquette, J. Am. Chem. Soc. 1984, 106, 6868.

3. “Regiocontrolled Synthesis of Mono-, Di- and Tri-substituted Cyclohexenones by Cycloaddition of Vinyl Sulfones to 1-Methoxy-3-[(trimethylsilyl)oxy]-1,3-butadienes. Conversion of Alkenes into Effective Dienophilic Reagents” W. A. Kinney, G. D. Crouse, L. A. Paquette, J. Org. Chem. 1983, 48, 4986.

2. “A Vinyl Sulfone-Mediated Diels-Alder Approach to the Fully Regiocontrolled Elaboration of 4,5-Disubstituted 2- and 3-Cyclohexenones” L. A. Paquette, W. A. Kinney, Tetrahedron Lett. 1982, 5127.

1. “A New Synthon for the Regiospecific gamma-Alkylation of 2-Cyclohexenones. Application to the Synthesis of Zingiberinol and Oxygenated Bicyclo[3.3.1]nonanes” L. A. Paquette, W. A. Kinney, Tetrahedron Lett.1982, 131.